Non-coding RNA Era is Dawning
نویسندگان
چکیده
Up to 90% of eukaryotic genomes are transcribed. Only ~ 2% of these transcripts encode proteins, while remaining 98% are ncRNAs [1,2]. ncRNAs can be categorized into infrastructural ncRNAs and regulatory ncRNAs. Constitutively expressed infrastructural ncRNAs include ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs). Based on their size, regulatory ncRNAs can be grossly classified into small (˂200nt) ncRNAs encompassing small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs), and long ( ˃200nt) non-coding RNAs (lncRNAs) [2-4].
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